FEED SUPPLEMENT FOR HORSES TO SUPPORT NORMAL FERTILITY
WHICH HORSES BENEFIT FROM OESTROVUM SUPPLEMENTATION?
OESTROVUM is a feed supplement to support fertility in horses and to balance the hormones.
OESTROVUM is ideal
- to prepare mares for pregnancy;
- for mares with fertility issues;
- for older mares (12+); and
- for moody mares with "marish" behaviour.
Fertility issues in stallions can also be caused by estrogen dominance. In these cases OESTROVUM can help to balance the estrogen metabolism in stallions. Consult your veterinarian for advice.
WHY SHOULD I GIVE OESTROVUM TO MY HORSE OR PONY?
Diseases of the endometrium are a frequent cause of infertility in mares. 64% of clinically healthy mares has a certain degree of fibrosis (endometrosis) in the uterus that aggravates with age (1).
EXCESSIVE LOCAL ACTION OF THE HORMONE ESTROGEN HAS A NEGATIVE IMPACT ON THE HEALTH AND DEFENSE OF THE ENDOMETRIUM (2).
Estrogens are produced and excreted every day. They are broken down in the liver in two phases. This detoxification process can be disturbed when the liver also has to break down many other toxic substances, such as pesticides, medicines and other hormone- disrupting substances in the environment and drinking water.
When detoxification is disturbed, phase II (methylation) is slower than phase I, causing the accumulation of harmful intermediates that have a strong local estrogen effect and negative impact on the health and defence of the endometrium (2).
OESTROVUM is a feed supplement for horses and ponies, that helps to balance the hormones by
stimulating the breakdown of estrogens via the liver (METHYLATION)
Broccoli powder helps to reduce the formation of harmful estrogen intermediates during breakdown in the liver in phase I and stimulates the breakdown enzymes in phase II (3,4).
Folic acid, vitamin B12, choline and betaine are important nutrients for the proper functioning of methylation (phase II) (5,6).
Cysteine is a building block of the very powerful antioxidant glutathione. When methylation is disturbed, glutathione production will also be disturbed, leading to cell damage and reduced fertility (7).
Natural vitamin E is also a very good antioxidant that helps to prevent cell damage (8).
modulating the production of estrogens
Linseed reduces the production of estrogens by inhibiting the aromatase enzyme, responsible for the formation of estrogen from testosterone (9).
optimization of genetic potential (EPIGENETICS)
An optimal development of the embryo in the uterus through the supplementation of folic acid, vitamin B12, choline and betaine is of great importance to optimise the genetic potential of the foal in his adult life (10).
(1) Lehmann J et al., 2011
(2) Mijatovic V et al., 2019
(3) Fowke JH et al., 2000
(4) Valente Pereira FM et al., 2002
(5) Waterland RA et al., 2008
(6) Swegen et al., 2017
(7) Ebisch IMW et al., 2006
(8) Fagan et al., 2020
(9) Samavat H & Kurzer M, 2015
(10) Sinclair et al., 2007
WHAT'S INSIDE THE OESTROVUM?
Additives per kg
Betaine (3a920): 100 gr
Choline chloride (3a890): 60 gr
Vitamin E (d-alpha-tocopherol): 32.800 IU
Folic acid (3a316): 2.000 mg
Vitamin B12 (cyanocobalamine): 800 mg
HOW MUCH OESTROVUM SHOULD I GIVE TO MY HORSE OR PONY?
DAILY DOSAGE FOR A HORSE (500 kg body weight)
- First three months: 1 measuring cup (15 gram)
- After three months: 1/2 measuring cup
DAILY DOSAGE FOR A PONY (250 kg body weight)
- First three months: 1/2 measuring cup (7,5 gram)
- After three months: 1/4 measuring cup
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