Endometrosis is the most important“silent” cause of infertility in mares.

64% of clinically healthy mares has a certain degree of endometrosis in the uterus that aggravates with age (1).

Estrogens are produced and excreted every day. They are broken down in the liver in two phases. 

This detoxification can be disturbed when the liver also has to break down many other toxic substances, such as pesticides, medicines and other hormone-disrupting substances in the environment and drinking water. 

When detoxification is disturbed, phase II (methylation) is slower than phase I, causing the accumulation of harmful intermediates that have a strong local estrogen effect and cause endometrosis (2).

Broccoli powder helps to reduce the formation ofharmful estrogen intermediates during breakdownin the liver in phase I and stimulates the breakdown enzymes in phase II (3,4). 

Folic acid, vitamin B12, choline and betaine areimportant nutrients for the proper functioning ofmethylation (phase II) (5,6).  

Cysteine is a building block of the very powerful antioxidant glutathione. When methylation is disturbed, glutathione production will also be disturbed, leading to cell damage and reduced fertility (7). 

Natural vitamin E is also a very good antioxidant that helps to prevent cell damage (8).

Linseed reduces the production of estrogens by inhibiting the aromatase enzyme, responsible for the formation of estrogen from testosterone (9).

(1) Lehmann J et al., 2011

(2) Mijatovic V et al., 2019

(3) Fowke JH et al., 2000

(4) Valente Pereira FM et al., 2002

(5) Waterland RA et al., 2008

(6) Swegen et al., 2017

(7) Ebisch IMW et al., 2006

(8) Fagan et al., 2020

(9) Samavat H & Kurzer M, 2015