A few seasons back, I got a call from Charlotte, a client who’d been trying to get her mare pregnant for two solid years.
She tried everything:
- Fresh semen from proven stallions
- Expert reproductive exams (swabs, ultrasounds, …)
- Perfect timing for insemination
- Even hormone therapy
Still, the mare stayed open. Or she’d catch briefly… only to lose the embryo a few weeks later.
The heartbreak was real. Charlotte was ready to give up. That’s when I decided to apply a brand-new approach. I’d just finished training in phytotherapy and nutrition. One concept leapt out at me: methylation.
I know—methylation sounds like a boring biochem term. But it’s actually vital.
It’s what helps your mare’s body switch certain genes on and off. It helps keep uterine tissue healthy, her hormones in balance, and early embryo development on track.
Turns out many mares are missing key “methyl donors” in their diet. Without those building blocks, crucial fertility processes can fizzle out.
Worse, 66% of mares over ten show signs of uterine scarring (Ebert et al., 2014). That scarring (also called “endometriosis”) can block embryo implantation and trigger early pregnancy loss.
Once I wrapped my head around this, I started Charlotte’s mare on a specialized mix of prenatal nutrients—loaded with the active form of folate, vitamin B, choline, betaine and broccoli sprout powder to keep her body’s methylation running full speed.
Boom. She caught on the very next cycle… and carried to term.
At first, I thought, “It could be a fluke.” But the results kept repeating with other “problem mares.” So I refined the formula, tested it in collaboration with more than 600 vets.
We saw the same story repeatedly—mares that used to lose their embryos or never catch at all… finally carrying healthy foals.
That formula became Fresh&Fertile.
Eventually, I partnered with Ghent University and veterinarian Eileen Geerinckx on a clinical trial. The clinical trial, including over 30 mares, showed that Fresh&Fertile had a significant positive effect on embryo development in mares.
And ever since, vets and horse owners have been seeing incredible results...
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Veterinarian Lies De Rudder
"I failed to get the mare pregnant for three years despite regular cycles and good-quality semen. After 3-months of Fresh & Fertile, the mare successfully became pregnant without the use of any other products."
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Veterinarian Evelien Holvoet
"Mare year after year not pregnant or losing the foal early in pregnancy. Given Fresh & Fertile for 3 months, and this year pregnant immediately after the first covering!"
But how does it work? And why haven’t you heard of it before?
1. It addresses the methylation gap.
Methylation is like an internal set of “on/off switches” for thousands of genes in your mare’s body. Each gene needs a tiny “key” (a methyl group) to unlock it and work properly. If your mare doesn’t get enough methyl donors from her feed—or if those methyl donors are used up to detoxify other chemicals in the body—those keys go missing. As a result, critical genes that prevent uterine scarring can stay locked, egg quality can suffer, and the earliest stages of embryo development may stall before they even get started.
2. It balances reproductive hormones naturally.
High estrogen levels can wreck fertility. So, I included botanical extracts, like broccoli powder rich in indole-3-carbinol and flaxseed, rich in lignans, to support a healthy hormone balance (Fowke et al., 2000).
3. It fuels early embryonic support.
Active folate (5-methyl-tetrahydrofolate) is crucial for DNA replication in that delicate first month. We also added choline & betaine—key methyl donors—to keep everything running smoothly (Sinclair et al., 2007; Rizzo & Sciorsci, 2019).
4. It’s a complete pre & post-natal system.
Some owners feed “pregnancy supplements” only after they know the mare is in foal. But in my experience—and in human medicine, too—it’s best to start months before insemination. Fresh&Fertile is designed for use three months pre-breeding, all the way through pregnancy and lactation.
Many breeding protocols overlook whole-body nutritional health...
They focus on the reproductive tract—when ironically, the root of the issue often lies in the mare’s overall metabolism.
Consider the story of Dr. Lies De Rudder, who tried Fresh&Fertile on an Arabian mare intended for embryo flushing. Ultrasound always looked okay, the stallion’s semen was prime, but nothing ever took. She fed Fresh&Fertile for three months, then covered the mare. This time? Pregnant on the first attempt.
Or veterinarian Evelien Holvoet, who wrote to me about a mare that repeatedly lost the embryo before day 30. She tested negative for infections—everything seemed normal. Once we added Fresh&Fertile, the mare finally carried the embryo beyond that critical early window.
We’ve seen this over and over. And while nothing works 100% of the time (some mares have deeper structural issues), it’s become clear that supporting methylation is the missing link in so many “unexplained” fertility cases.
So what’s actually in Fresh&Fertile?
Active Folate (5-methyl-tetrahydrofolate)
Unlike common folic acid, active folate is ready to use in the body. Folic acid supports healthy cell division, which is crucial in the early stages of pregnancy when the embryo’s cells multiply at lightning speed. Plus, it promotes a healthier uterine environment—giving the developing foal a stronger foundation from day one.
Choline & Betaine
The heavy hitters that supply fresh “methyl groups.” They help keep homocysteine levels in check (key for pregnancy) and support normal gene expression in the uterus (Rizzo & Sciorsci, 2019).
Vitamin B12 & Vitamin B6
Extra co-factors for DNA synthesis, healthy blood cells, and nerve signals. Also vital for embryo development (Swegen et al., 2017).
Vitamin E (d-alpha-tocopherol)
An antioxidant that helps with everything from placental health to postpartum recovery. Horses lacking vitamin E can have trouble conceiving and maintaining pregnancy (Ishii et al., 2002).
Broccoli Powder
A natural source of indoles (like indole-3-carbinol) that help the liver process excessive estrogens. Balanced estrogen is key for a stable cycle and better embryo retention (Fowke et al., 2000).
Flaxseed (high in Lignans)
Lignans help regulate hormone levels and give added support to your mare’s overall reproductive system. Plus, flaxseed offers fiber and omega-3s for a healthier gut and improved metabolic function.
All of these ingredients are doping-free, tested, and safe to feed during FEI competitions (read our clean sport policy here). Each batch meets strict standards because we know your mare’s health and foal’s future are on the line.
Maybe you’re thinking, “But I’ve already spent so much on semen, shipping, vet bills—why risk more money on yet another supplement?”
Simple. This is the prenatal approach for mares. Human moms don’t wait to be pregnant before taking folate—they start as soon as they consider having a baby. Our mares deserve the same.
Think about it: every unsuccessful cycle can cost you big in extra vet visits, lost time, and frustration. If you can boost your mare’s odds of a healthy, stable pregnancy, it saves you money in the long run. More importantly, it might save you the heartbreak of seeing your mare slip an embryo again.
Why is this so urgent?
The breeding window is finite. Each lost season puts you a year behind in your program. Older mares accumulate more scarring and are tougher to get in foal. If you wait, you could watch her slip into another empty cycle with no real changes in approach.
But add a proper nutritional foundation now, and you’ll lay the groundwork for better follicle development, improved uterine health, and a more viable embryo from day one.
Just imagine the vet’s next ultrasound showing that precious flickering heartbeat, instead of yet another “I’m sorry…she’s open.”
Ready to give Fresh&Fertile a try?
Here’s how to get started:
- Order a supply that gets you at least three months of coverage before breeding.
- 500 g - 1 month supply
- 1500 g - 3 months supply (15% cheaper)
- Subscription (recurring order with automatic payments gives you another 10% off)
- Feed 15g daily or 1 measuring scoop (for a 500 kg horse) —no complicated instructions, no weird mixing.
- Continue through pregnancy (yes, it’s safe—actually recommended).
- Watch your mare’s condition improve as she finally has the nutrients and methyl donors she needs.
We’ve seen it change the game for mares people called “impossible to breed.” It could change everything for you, too.
Here is what our customers have to say about Fresh&Fertile
We've helped 30.000+ horses
Frequently asked question
Fresh&Fertile’s strong odour comes from broccoli sprout powder, which is rich in sulfur, helping your mare metabolize hormones, supports healthy uterine tissue, and boosts antioxidant defences to promote fertility.
Introduce Fresh&Fertile gradually.
If your mare finds the smell off-putting, we recommend phasing it in slowly to get her used to the scent and taste:
Week 1: Start with ¼ of the daily dose.
Week 2: Increase to ½ dose.
Week 3: Work up to the full daily dose.
Mix it into her favourite feed or a palatable mash. If you’re using a wet mash, add Fresh&Fertile just before serving, so it doesn’t soak for too long and lose potency.
Over time, most horses adjust to the smell and consume it without fuss.
We recommend starting Fresh&Fertile at the beginning of the fertility season (January–February) or 3 months before your planned insemination or covering date. Continue feeding it every day throughout pregnancy and lactation.
Yes. We even encourage it. Fresh&Fertile contains vital nutrients like folic acid, which are essential for foal development. Keeping your mare on Fresh&Fertile during lactation also helps rebalance her hormones after foaling.
In most cases, yes. Fresh&Fertile is typically safe to use alongside standard veterinary medications. However, we always advise discussing it with your vet first, just to be sure it aligns with your mare’s specific treatment plan.
A clinical study was led by veterinarian Eileen Geerinckx and Ghent University. You can read it here. It offers a detailed look at how Fresh&Fertile supports mare fertility in real-world conditions.
Yes. Fresh&Fertile works well with other products in our range. For pregnant mares, a typical regimen often includes:
- Fresh&Fertile: Start 3 months before insemination, continue throughout pregnancy and lactation.
- Grow&Glow: Begin in the third trimester to provide extra energy for the mare. Its omega-3 fatty acids also support the foal’s immune system through the milk.
- Guts&Glory: Use from early pregnancy through lactation to promote a healthy gut microbiome for both mare and foal.
Yes. It’s safe for use in FEI competitions. Each batch is tested for common banned substances and meets clean-sport guidelines. You can read more about our Clean Sport Policy here.
Orders placed on weekdays before 10 am will be shipped on the same day. Orders placed after 10 am will be shipped the following day. Orders placed on weekends or holidays will be shipped on the next business day.
- Orders within Belgium, shipped via Bpost, will usually arrive within 1 to 3 business days.
- Orders outside Belgium, shipped with DPD, will usually arrive within 2 to 5 business days.
Our products are made and shipped from Belgium.
All our products are formulated by a team of leading experts, including our Co-Founder Veterinarian Valerie De Clerck, as well as a Biochemist and Professor of Pharmacology.
We source the ingredients for our supplements from some of the highest-quality suppliers around the world. We then manufacture the final products in ISO 22000, FCA (GMP+) and bio-certified facilities in Belgium.
Our products are up to 99% natural. Where possible we source natural ingredients for our products. In the small number of cases where it’s virtually impossible to get natural ingredients for some formulations, we use synthetic ones.
Yes! By our Co-Founder Veterinarian Valerie De Clerck as well as a whole host of Veterinarians who have been using our products with their clients’ horses for years. In fact, 9/10 vets recommend Curafyt supplements.
Simply email us at info@curafyt.com or just use the chat at the bottom right corner of the page. Our team will get back to you asap.