Glycyrrhiza glabra

Liquorice root

Hormonal balance support

Liquorice root contains glycyrrhizin, a bioactive compound known to influence cortisol metabolism by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). By slowing the conversion of cortisol into inactive cortisone, glycyrrhizin can help maintain normal cortisol availability in the body, which plays a role in metabolic regulation and stress responses.

Cortisol signaling is closely connected with the hypothalamic–pituitary–adrenal (HPA) axis, a key hormonal system involved in energy metabolism, stress adaptation, and endocrine balance. Research also suggests that liquorice-derived compounds can interact with neuroendocrine pathways linked to neurotransmitters such as dopamine.

Because hormonal balance and metabolic signaling are closely linked, botanicals such as liquorice are sometimes included in nutritional strategies aimed at supporting metabolic resilience in animals prone to weight gain or dietary sensitivity. Asl & Hosseinzadeh, 2008; Armanini et al., 2002

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Southern Europe / Mediterranean region

Root

This ingredient is used in