The Fertility Formula: Clinically proven supplement improves your mare's chances of conceiving this season

A few seasons back, I got a call from Charlotte, a client who’d been trying to get her mare pregnant for two solid years.

She tried everything 😩 :

• Fresh semen from proven stallions

• Expert reproductive exams (swabs, ultrasounds, …)

• Perfect timing for insemination

• Even hormone therapy

Still, the mare stayed open. Or she’d catch briefly… only to lose the embryo a few weeks later.

The heartbreak was real. Charlotte was ready to give up. That’s when I decided to apply a brand-new approach. I’d just finished training in phytotherapy and nutrition. One concept leapt out at me: methylation. ➡️📖 

I know—methylation sounds like a boring biochem term. But it’s actually vital. It’s what helps your mare’s body switch certain genes on and off. It helps keep uterine tissue healthy, her hormones in balance, and early embryo development on track.

Turns out many mares are missing key “methyl donors” in their diet. Without those building blocks, crucial fertility processes can fizzle out. Worse, 66% of mares over ten show signs of uterine scarring (Ebert et al., 2014). That scarring (also called “endometriosis”) can block embryo implantation and trigger early pregnancy loss.

"66% of mares over ten show signs of uterine scarring (also called endometrosis)"

Once I wrapped my head around this, I started Charlotte’s mare on a specialized mix of prenatal nutrients—loaded with the active form of folate, vitamin B, choline, betaine and broccoli sprout powder to keep her body’s methylation running full speed.

Boom. She caught on the very next cycle…and carried to term. 🎉

At first, I thought, “It could be a fluke.” But the results kept repeating with other “problem mares.” So I refined the formula, tested it in collaboration with more than 600 vets. We saw the same story repeatedly—mares that used to lose their embryos or never catch at all…finally carrying healthy foals. That formula became Fresh&Fertile.

Eventually, I partnered with Ghent University and veterinarian Eileen Geerinckx on a clinical trial. The clinical trial, including over 30 mares, also showed that Fresh&Fertile had a significant positive effect on embryo development in mares.

But how does it work? And why haven’t you heard of it before?

1. It addresses the methylation gap.
Methylation is like an internal set of “on/off switches” for thousands of genes in your mare’s body. Each gene needs a tiny “key” (a methyl group) to unlock it and work properly. If your mare doesn’t get enough methyl donors from her feed—or if those methyl donors are used up to detoxify other chemicals in the body—those keys go missing. As a result, critical genes that prevent uterine scarring can stay locked, egg quality can suffer, and the earliest stages of embryo development may stall before they even get started.

2. It balances reproductive hormones naturally.
High estrogen levels can wreck fertility. So, I included botanical extracts, like broccoli powder rich in indole-3-carbinol and flaxseed, rich in lignans, to support a healthy hormone balance (Fowke et al., 2000).

3. It fuels early embryonic support.
Active folate (5-methyl-tetrahydrofolate) is crucial for DNA replication in that delicate first month. We also added choline & betaine—key methyl donors—to keep everything running smoothly (Sinclair et al., 2007; Rizzo & Sciorsci, 2019).

4. It’s a complete pre & post-natal system. Some owners feed “pregnancy supplements” only after they know the mare is in foal. But in my experience—and in human medicine, too—it’s best to start months before insemination. Fresh&Fertile is designed for use three months pre-breeding, all the way through pregnancy and lactation.

Many breeding protocols overlook whole-body nutritional health. They focus on the reproductive tract—when ironically, the root of the issue often lies in the mare’s overall metabolism.

Consider the story of Dr. Lies De Rudder, who tried Fresh&Fertile on an Arabian mare intended for embryo flushing. Ultrasound always looked okay, the stallion’s semen was prime, but nothing ever took. She fed Fresh&Fertile for three months, then covered the mare. This time? Pregnant on the first attempt.

Or veterinarian Evelien Holvoet, who wrote to me about a mare that repeatedly lost the embryo before day 30. She tested negative for infections—everything seemed normal. Once we added Fresh&Fertile, the mare finally carried the embryo beyond that critical early window.

We’ve seen this over and over. And while nothing works 100% of the time (some mares have deeper structural issues), it’s become clear that supporting methylation is the missing link in so many “unexplained” fertility cases.

So what’s actually in Fresh&Fertile?

• Active Folate (5-methyl-tetrahydrofolate)
  Unlike common folic acid, this form is ready to use in the body. Folic acid supports healthy cell division, which is crucial in the early stages of pregnancy when the embryo’s cells multiply at lightning speed. It also helps maintain proper red blood cell production, keeping your mare energized and her tissues well-oxygenated. Plus, it promotes a healthier uterine environment—giving the developing foal a stronger foundation from day one.
  
  
• Choline & Betaine
  The heavy hitters that supply fresh “methyl groups.” They help keep homocysteine levels in check (key for pregnancy) and support normal gene expression in the uterus (Rizzo & Sciorsci, 2019).
  
  
• Vitamin B12 & Vitamin B6
  Extra co-factors for DNA synthesis, healthy blood cells, and nerve signals. Also vital for embryo development (Swegen et al., 2017).
  
  
• Vitamin E (d-alpha-tocopherol)
  An antioxidant that helps with everything from placental health to postpartum recovery. Horses lacking vitamin E can have trouble conceiving and maintaining pregnancy (Ishii et al., 2002).
  
  
• Broccoli Powder
  A natural source of indoles (like indole-3-carbinol) that help the liver process excessive estrogens. Balanced estrogen is key for a stable cycle and better embryo retention (Fowke et al., 2000).
  
  
• Flaxseed (High in Lignans)
  Lignans help regulate hormone levels and give added support to your mare’s overall reproductive system. Plus, flaxseed offers fiber and omega-3s for a healthier gut and improved metabolic function.

All of these ingredients are doping-free, tested, and safe to feed during FEI competitions (read our clean sport policy here). Each batch meets strict standards because we know your mare’s health and foal’s future are on the line.

How do you use it?

Just sprinkle 15g per day into your mare’s feed. Start about three months before you plan to breed. Keep it going through the entire pregnancy and lactation. It’s that straightforward.

Maybe you’re thinking, “But I’ve already spent so much on semen, shipping, vet bills—why risk more money on yet another supplement?”

Simple. This is the prenatal approach for mares. Human moms don’t wait to be pregnant before taking folate—they start as soon as they consider having a baby. Our mares deserve the same.

Think about it: every unsuccessful cycle can cost you big in extra vet visits, lost time, and frustration. If you can boost your mare’s odds of a healthy, stable pregnancy, it saves you money in the long run. More importantly, it might save you the heartbreak of seeing your mare slip an embryo again.

Why is this so urgent?

The breeding window is finite. Each lost season puts you a year behind in your program. Older mares accumulate more scarring and are tougher to get in foal. If you wait, you could watch her slip into another empty cycle with no real changes in approach.

But add a proper nutritional foundation now, and you’ll lay the groundwork for better follicle development, improved uterine health, and a more viable embryo from day one.

Just imagine the vet’s next ultrasound showing that precious flickering heartbeat, instead of yet another “I’m sorry…she’s open.”

Ready to give Fresh&Fertile a try?

Here’s how to get started:

1. Order a supply that gets you at least three months of coverage before breeding.

- 500 g - 1 month supply
- 1500 g - 3 months supply (15% cheaper)
- Subscription (recurring order with automatic payments gives you another 10% off)

2. Feed 15g daily or 1 measuring scoop (for a 500 kg horse) —no complicated instructions, no weird mixing.

3. Continue through pregnancy (yes, it’s safe—actually recommended).

4. Watch your mare’s condition improve as she finally has the nutrients and methyl donors she needs.

We’ve seen it change the game for mares people called “impossible to breed.” It could change everything for you, too.

If you’re tired of throwing money at short-term fixes…if you’re ready to give your mare the same advantage we’d give ourselves (prenatal vitamins, not just waiting until we’re pregnant)…then Fresh&Fertile is for you.

Order now. Feed it daily. Let your mare’s body do the rest.

Because the joy of seeing that little foal bouncing at her side? That’s what makes all the effort and investment worthwhile.

Let’s make that happen—together,

Veterinarian Valerie 👩⚕️🩺